AGREE II Instrument

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The Checklist for the Reporting of Updated Guidelines (CheckUp) has recently been published in PLoS Medicine. This has been the result of a partnership of the Iberoamerican Cochrane Centre (, the AGREE Collaboration (, and the G-I-N Updating Guidelines Working Group (

CheckUp can be used to evaluate the completeness of reporting in updated guidelines and as a tool to inform guideline developers about reporting requirements.

CheckUp was developed through a comprehensive process, including the use of systematic reviews, assessment of updated clinical guidelines, and engagement of the international guideline community through semistructured interviews, a Delphi consensus survey, and an external review.

Adherence to CheckUp will likely enhance the comprehensiveness and transparency of clinical guideline updating for the benefit of patients and the public, health care professionals, and other relevant stakeholders.

Reference: Vernooij RWM, Alonso-Coello P, Brouwers M, Martínez García L, CheckUp Panel (2017) Reporting Items for Updated Clinical Guidelines: Checklist for the Reporting of Updated Guidelines (CheckUp). PLOS Medicine 14(1): e1002207. doi: 10.1371/journal.pmed.1002207.

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