AGREE II Instrument

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The original AGREE Instrument

The AGREE Instrument quickly became the international gold standard for practice guidelines evaluation and development.

Since its original release in 2003, the Appraisal of Guidelines for Research and Evaluation (AGREE) Instrument has advanced the science of practice guidelines (PG) appraisal and quickly became the international gold standard for PG evaluation and development.

The AGREE Instrument has been translated into many languages, endorsed by several organizations (e.g., National Institute for Health and Clinical Excellence), and used by many development groups (e.g., WHO Advisory Committee on Health Research).

The original AGREE paper has had a wide impact; an analysis of the ISI Web of Science found that between its publication in 2003 and December 2008, there were 139 citations, with its number increasing every year.

We recommend the use of the new AGREE II in place of the original AGREE Instrument.